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dc.contributor.authorFossum, Guro Haugen
dc.contributor.authorLindbæk, Morten
dc.contributor.authorGjelstad, Svein
dc.contributor.authorKvaerner, Kari Jorunn
dc.date.accessioned2022-06-28T07:46:10Z
dc.date.available2022-06-28T07:46:10Z
dc.date.created2018-10-09T12:30:46Z
dc.date.issued2018
dc.identifier.citationAntibiotics, 7(3), 84.en_US
dc.identifier.issn2079-6382
dc.identifier.urihttps://hdl.handle.net/11250/3001216
dc.description.abstractAntibiotics are the most frequent prescription drugs used by pregnant women. Our objective was to investigate if the dispensation of antibiotics and antiasthmatics in children less than 1 year of age is associated with prenatal antibiotic exposure. A secondary aim was to explore the incidence of dispensed antibiotics in pregnancy and dispensed antibiotics and antiasthmatics in children. We conducted an observational study using the Peer Academic Detailing study database to select patients eligible for match in the Medical Birth Registry of Norway, a total of 7747 mother-and-child pairs. Details on antibiotic and antiasthmatic pharmacy dispensations were obtained from the Norwegian Prescription Database. One quarter (1948 of 7747) of the mothers in the study had been dispensed antibiotics during pregnancy. In their first year of life, 17% (1289) of the children had had an antibiotic dispensation, 23% (1747) an antiasthmatic dispensation, and 8% (619) of the children had had both. We found a significant association between dispensed antibiotics in pregnancy and dispensed antibiotics to the child during their first year of life; OR = 1.16 (95% CI: 1.002–1.351). The association was stronger when the mothers were dispensed antibiotics at all, independent of the pregnancy period; OR = 1.60 (95% CI: 1.32–1.94). We conclude that the probability for dispensation of antibiotics was increased in children when mothers were dispensed antibiotics, independent of pregnancy. Diagnostic challenges in the very young and parental doctor-seeking behavior may, at least in part, contribute to the association between dispensations in mothers and children below the age of one year.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectantibacterial agentsen_US
dc.subjectpregnancyen_US
dc.subjectchildrenen_US
dc.subjectasthma medicationen_US
dc.subjectpharmacoepidemiologyen_US
dc.titleRelationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmaticsen_US
dc.title.alternativeRelationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmaticsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderThe Authorsen_US
dc.source.volume7en_US
dc.source.journalAntibioticsen_US
dc.source.issue3en_US
dc.identifier.doi10.3390/antibiotics7030084
dc.identifier.cristin1618990
dc.relation.projectNorges forskningsråd: 237766en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal